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Metametrix 0087 DNA/Oxidative Stress Marker (8OH-2’-deoxyguanosine)

Estimated turn-around: 10-12 days

The interaction of reactive oxygen species with DNA and RNA produces oxidation products of these base rings. DNA repair enzymes must remove the damaged bases in order to maintain viability. Oxidation of guanosine produces 8-hydroxy-2′-deoxyguanosine (8OHdG). The concentration of 8OHdG in urine has been shown to be an accurate measure of the rate of polynucleotide oxidative damage. Elevated 8OHdG is a sign that antioxidant nutrient intake may need to be increased. Toxicants and lifestyle stress factors may contribute to increased oxidative challenge

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Metametrix 0051 Lipid Peroxides (TBARS)

Estimated turn-around: 10-12 days

Lipid peroxides are the products of chemical damage done by oxygen free radicals to the polyunsaturated fatty acids of cell membranes. This test is an assay of total thiobarbituric acid-reactive substances (TBARS) in serum using HPLC. The HPLC separation step isolates the TBARS from potential interfering compounds that can give false elevations in a simple colorimetric assay. The results provide a measure of total serum lipid peroxidation, an indicator of whole body free radical activity. High levels of lipid peroxides are associated with cancer, heart disease, stroke, and aging.

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